This collection contains data for the paper "African biomass burning affects aerosol cycling over the Amazon" (Holanda et al., 2023, doi:10.1038/s43247-023-00795-5). When using the data, please refer to the paper mentioned above. If further data are needed, please contact the corresponding authors. The files contain several atmospheric parameters measured at the ATTO (Amazon Tall Tower Observatory) site over the years 2019 and 2020 as well as measurements onboard the High Altitude and Long Range (HALO) research aircraft in the course of two intensive campaigns (ACRIDICON-CHUVA in Sep-Oct 2014 and CAFE-Africa in Aug-Sep 2018).