Evolution of the activation steps in the vertebrate phototransduction cascade analysed using agnathan eye transcriptomes

Vertebrate phototransduction represents the best understood example of response activation in a G protein cascade. Not only have the protein components been characterised comprehensively, but in addition the molecular mechanisms that mediate high amplification and rapid response kinetics are understood in sufficient detail to predict the onset phase of the response to light absorption. Although the phylogeny of the phototransduction proteins has been studied extensively in jawed vertebrates (gnathostomes), there is a paucity of information about the corresponding proteins in the jawless branch of vertebrates (agnathans), from which gnathostomes diverged around 500 million years ago. The only surviving jawless vertebrates are lampreys (around 40 species) and hagfish (around 80 species). We have applied high-throughput sequencing to eye tissue from one species of hagfish, two species of lamprey and five species of gnathostome fish, to obtain mRNA sequences for the components of the phototransduction cascade

Identifier
Source https://data.blue-cloud.org/search-details?step=~012E565B9D341735B5E27D6A1B1FCE6C9719E03E8F0
Metadata Access https://data.blue-cloud.org/api/collections/E565B9D341735B5E27D6A1B1FCE6C9719E03E8F0
Provenance
Instrument Illumina HiSeq 2500; Illumina HiSeq 2000; ILLUMINA
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Point 2016-08-07T00:00:00Z