This BAG coordinates activities of groups from the South of the UK. The focus is on projects in immunology, transcriptional regulation, and enzymology. Particular strengths are antimicrobial resistance research (AMR), drug development, and the macromolecular complexes that several of our groups target. A highlighted presented with mid-term report is rational drug design for antibodies (biologicals) in cancer immunology (Southampton). We are interested in dynamic structural biology and use spectroscopy and SAXS in addition to gain this insight; several members of this bag are also active users of ID29 serial. Our projects listed here apply for time on crystallographic beamlines, SAXS, and spectroscopy (BM07 and icOS).