22 datasets found

We have recently developed novel ternary lipopolyplex vectors (i.e. gene delivery vectors containing cationic lipid, plasmid DNA and a cationic peptide) in which, for the first...

The efficiency of silicon solar cells is limited to 29%. One possible way of breaking this limit uses a process called singlet fission, converting a high energy photon into two...

Coating two surfaces with polymer brushes has been shown on many occasions to reduce friction by orders of magnitude. These ultra-low frictions are believed to stem from be the...

In a recent series of successful experiments at PSI and ISIS we were able to demonstrate the possibility of measuring the rate of transfer of a small molecule (allyl alcohol)...

The (NH4)0.02 Rbx K0.98-x I system offers advantages for the systematic study of tunnelling species and how they interact. Currently there are two models to explain the dynamics...

Small particles with dimensions of a few hundred nanometers tend to behave differently when confined in small spaces. Examples of such situations are easy to find in nature --...

This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the...

In this proposal we will study the structure of metal-ammonia solutions containing single graphene sheets by exploiting H/D isotopic labelling in conjunction with NIMROD¿s...

At Kings College London we have recently developed a novel combination formulation, a nanosuspsomicroemulsion (NSME), comprising of a microemulsion (ME) containing one drug and...

It is commonly accepted that the recording of holograms with atomic resolution requires singlecrystalline samples. Closer analysis, however, shows that the reduced information...

Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex...

Co-crystals of 4-methylpyridine and pentachlorophenol (MP-PCP) exhibit the very unusual property of isotopic polymorphism, formation of different phases by samples differing...

Peptidomimetics are synthetic mimics of peptides, the natural building blocks of proteins, and their development is a growing field of science. An underlying theme in recent...

Controlled vesicle fusion has major advantages in diagnostic and drug delivery applications. We have designed a DNA hybridisation-based assay for directed fusion of vesicles...

Tolaasin is a lipodepsipeptide (lipo = hydrophobic side chain, depsipeptide is an amino acid ring closed in a particular way) produced by strains of Pseudomonas tolaasii, and it...

Poly(amidoamine) (PAMAM) dendrimers have been identified as potential gene vectors. We have studied their association with surfactants, dilauroylphospholiponucleosides (DLPN),...

Peptide-functionalized nanoparticle (NP) aggregates have significant potential as biosensors (for specific enzymes) due to their high sensitivity, modular design and simple...

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

Calcium carbonate is one of the most abundant minerals at the Earth’s surface and plays a large role in the chemistry of aquatic environments, as well as being the main...

Storing the energy available from the sun as a fuel that can be used anytime is a major global challenge. Organic materials synthesised from abundant elements that can harness...