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Interfacial adsorption of monoclonal antibodies and antigen binding
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Heterogeneous protein exchange at the solid/liquid interface using deuterated...
The formation of protein layers on surfaces is important for medical implants and for the consequences of the ingestion of nanoparticles. In the body, a surface is exposed to a... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Protein exchange at the solid/liquid interface
The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins... -
Probing the effects of oxidative stress on the membrane binding of alpha-synu...
Neutron reflectometry will be used to characterise the cellular membrane binding interaction of alpha-synuclein under conditions mimicking oxidative stress. Alpha-synuclein is... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Counterion binding to nonionic micelles: effect on interactions with silica
This proposal continues our research on ion binding to surfactant micelles. Our recent work demonstrates that the details of water structure around micelles are now accessible... -
Oriented antibody binding layers
The proposal concerns the assembly of high density antibody binding surfaces to increase the sensitivity of medical diagnostics. Previously we showed that antibody binding... -
Characterising anion binding by analysis of the electron density distribution
The aim of our work is to use charge density analysis to gain insight into the process of binding relatively small anions by specifically designed small organic molecules. These... -
Conformational change of glycerol faciliitator protein on substrate binding
A large family of membrane channel proteins selective for transport of water (aquaporins) or water plus glycerol (aquaglyceroporins) has been found in diverse life forms. E.... -
Interlayer and Interparticle Water in Clays
Clay barriers are routinely used in nuclear waste repositories to isolate radionuclides from the biosphere. Such barriers have to be carefully designed to remain effective for... -
The Kinetics of Self-Exchange of a Protein at Solid/Liquid interfaces
The formation of a protein corona occurs on all surfaces exposed to biological systems and understanding of how this corona forms is vital for many aspects of medicine and for... -
Interfacial adsorption of monoclonal antibody and antigen binding
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Lagtimes in the adsorption of proteins at the air/water interface
Adsorption of proteins at all surfaces has a characteristic lagtime which can be monitored by surface tension at the air/water interface. The cause of the lagtime is not... -
Selective recruitment of cholesterol to lipid rafts by multivalent protein bi...
Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by... -
Relation between surface tension and adsorbed amount of proteins at the air/w...
The surface tension of proteins often exhibits a reproducible lagtime, which is sensitiv to a range of conditions such as concentration, pH, ionic strength. We have also found... -
The role of tryptophan in puroindoline/purothionin cooperative binding to bio...
The puroindoline (PIN) and purothionin (PTH) families of polypeptides both occur in wheat and are implicated in antipathogenic defence mechanisms, and of interest for potential... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Characterising the membrane binding interaction of plant annexin Gh1
Annexins are a ubiquitous group of membrane associated proteins found in animals, plants and fungi. They are linked to wide range of functions including phospholipid...
