25 datasets found

This proposal seeks to investigate a class of synthetic membrane-active biopolymers which have been developed as potential drug-delivery agents. These polymers have shown pH-...

We have previously studied the adsorption of anti-beta-hCG at the hydrophilic silicon oxide/water interface and the subsequent binding by antigen hCG. We propose to extend this...

The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent...

Annexins are a ubiquitous group of membrane associated proteins found in animals, plants and fungi. They are linked to wide range of functions including phospholipid...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the...

The puroindoline (PIN) and purothionin (PTH) families of polypeptides both occur in wheat and are implicated in antipathogenic defence mechanisms, and of interest for potential...

The surface tension of proteins often exhibits a reproducible lagtime, which is sensitiv to a range of conditions such as concentration, pH, ionic strength. We have also found...

Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by...

Adsorption of proteins at all surfaces has a characteristic lagtime which can be monitored by surface tension at the air/water interface. The cause of the lagtime is not...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

The formation of a protein corona occurs on all surfaces exposed to biological systems and understanding of how this corona forms is vital for many aspects of medicine and for...

Clay barriers are routinely used in nuclear waste repositories to isolate radionuclides from the biosphere. Such barriers have to be carefully designed to remain effective for...

A large family of membrane channel proteins selective for transport of water (aquaporins) or water plus glycerol (aquaglyceroporins) has been found in diverse life forms. E....

The aim of our work is to use charge density analysis to gain insight into the process of binding relatively small anions by specifically designed small organic molecules. These...

The proposal concerns the assembly of high density antibody binding surfaces to increase the sensitivity of medical diagnostics. Previously we showed that antibody binding...

This proposal continues our research on ion binding to surfactant micelles. Our recent work demonstrates that the details of water structure around micelles are now accessible...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

Neutron reflectometry will be used to characterise the cellular membrane binding interaction of alpha-synuclein under conditions mimicking oxidative stress. Alpha-synuclein is...

The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins...