11 datasets found

This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...

In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...

We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we...

Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for...

The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿...

In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...

As research on apoptosis has gained momentum, the importance of membrane lipids in this crucial cellular process is becoming clear.Previously, we have determined using NR and...