56 datasets found

Comparison of conserved TAD boundaries reveals that diverging CTCF sites is an evolutionary conserved signature associated with TAD borders Overall design: 4C-seq samples for...

We mapped DNA methylation in 580 animal species (535 vertebrates, 45 invertebrates), resulting in 2443 genome-scale, base-resolution DNA methylation profiles of primary tissue...

EXPression AloNg Development and Evolution (EXPANDE) project aims to identify gene expression profiles expanded during embryogenesis and evolution. In brief, taking advantages...

To explore the function of the gene in spleen development, we generated a knockout zebrafish line. To investigate whether the phenotypic consequences in the seahorses were...

Part of the Vertebrate Genome Project, fish study. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the...

Signaling pathways control a large number of gene regulatory networks (GRNs) during animal development, acting as major tools for body plan formation. Remarkably, in contrast to...

For further information on this study please see http://www.sanger.ac.uk/resources/downloads/bacteria/campylobacter-jejuni.html This data is part of a pre-publication release....

TCR Repertoire sequencing raw reads TCR alpha and beta for several species

Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. While DNA methylation likely has a conserved role in gene silencing, the levels and...

Using hMeDIP-seq we validated the single-base resolution hydroxymethylomes (ACE-seq) of sea urchin, lancelet and zebrafish embryos. Overall design: hMeDIP-seq was perfomred on...

The brain requires complex mechanisms of genome regulation to encode and store behavioural information. In mammals, DNA methylation deposited at non-CG dinucleotides...

4C-seq experiments to study the evolution of the chromatin architecture of ancient gene regulatory blocks at the origin of vertebrates. Overall design: 4C-seq experiments...

North Atlantic marine snow (oil associated) microbial sequences

Signaling pathways control a large number of gene regulatory networks (GRNs) during animal development, acting as major tools for body plan formation. Remarkably, in contrast to...

This study determines that genome skimming, shallow depth of sequencing, is capable of accurately quantifying global DNA methylation level across a range of vertebrates.

What genomic changes led to the origin of vertebrates remains a mystery. On the one hand, animal evolution is thought to be driven mostly by changes in the cis-regulatory...

Whole-genome DNA-seq and strand-specific RNA-seq on 18 species, including 14 metazoans and four unicellular eukaryotes closely related to metazoans. For each species, two to...

Study somatic mutation in animal tissues, including mutation burden accumulation through lifespan and mutational signatures.

Using ACE-seq we investigated single-base resolution hydroxymethylomes of sea urchin, lancelet and zebrafish during development. Overall design: ACE-seq was perfomred on (i) 24...

We investigate tissue transcriptomic evolution across bilaterian animals by analyzing RNA-seq data from eight different tissues across twenty species. Overall design:...