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Molecular interactions and protein stability in the accessory gene regulator ...
Staphylococcus aureus is a normal skin commensal and an opportunistic pathogen that presents serious threat to healthcare. It is the causative agent of septicaemia and... -
Probing the thickness of the polymer adsorbed layer in HEUR stabilized oil in...
Oils are commonly used in personal care industry as emollients. Owing to their undesirable feel they are formulated in oil in water emulsions form. Emulsions contains... -
Structure determination of solution aggregation of single alkyl chain PC surf...
We have synthesised alkyl phosphorylcholine (CnPC) surfactants in hydrogenated and deuterated form and have determined their solution aggregation using SANS. In this part of... -
Biological small-angle neutron scattering on Zoom
This dataset has no description
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Further SANS contrast measurements on important protein/DNA interactions from...
This proposal is to perform further SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an... -
Further SANS contrast measurements on important protein/DNA interactions from...
This proposal is to perform further SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an... -
Is there a CMC for surfactants in non-aqueous solvents?
The aim of this project is to use SANS to determine if a critical micelle concentration (CMC) exists for the formation of inverse micelles in non-polar solvents. The CMC is a... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Solution structures of the immunologically important proteins IgA, IgG and C3
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
Developing a general approach to resolution of accessory proteins bound to cl...
Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex... -
Using SANS2D to determine the size of MscL clusters in proteoliposomes
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Structure-function studies of Replication Protein A, a crucial player in geno...
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
STRUCTURE OF THE COMPLEX BETWEEN CYTOCHROME P450 REDUCTASE AND CYTOCHROME C
Cytochromes P450 play a key role in drug metabolism in man. Electrons are supplied to the cytochromes by NADPH through the flavoprotein NADPH-cytochrome P450 reductase (CPR).... -
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Structural characterisation of a transmembrane biological electron conduit us...
Many bacteria are able to respire using solid minerals and metals as electron acceptors in the absence of oxygen or other diffusible substrates. In Shewanella oneidensis this... -
Building a model for gastric mucins
Gastric mucus is a vital component for the protection of the stomach from the highly acidic gastric secretions, preventing autodigestion and providing mechanical protection.... -
Reconstitution of human dihydroorotate dehydrogenase into lipid-detergent mic...
Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with... -
Contrast-matching experiments to quantify pore connectivity in dolomites
Geologists are increasingly realizing the unique perspective that neutron scattering offersforunlocking the complex geologic histories of rocks. In this study, we propose to... -
Effect of terminal blocking groups on solution aggregation of short peptide f...
Short peptide sequences such as KLVFFAE form well defined beta sheet structures. Their further templating through hydrophobic interactions and hydrogen bonding is the principal...
