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Interfacial adsorption of monoclonal antibodies and antigen binding
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
Adsorption of fatty acids at the calcite-liquid interface
The interface of CaCO3 (calcite) and water is of paramount importance in a number of key academic and industrial areas, including scale deposition in domestic and industrial... -
INTER as a new Tool to Follow the Dynamic Adsorption of Antibody and Non-ioni...
Following our very recent work on the dynamic co-adsorption of our control antibody COE-3 and nonionic surfactant PS80-7EO from the mixed solution, We request 3 days of Inter... -
Interfacial layer structure of designed linear lipopeptides
Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a... -
Novel dual purpose antimicrobials and co-formulates to regenerate currently r...
The increased prevalence of antimicrobial resistant bacteria is the most significant challenge facing the human-health today in both developed and developing worlds. It's... -
Modelling of surfactant phase behaviour versus concentration below ambient te...
We wish to understand how the concentration of surfactant mixtures in solution affects adsorption at lower temperatures; in particular, we wish to see how the composition of the... -
Interactions between Designed Antimicrobial Lipopeptides and Inner Membrane L...
Neutron reflection will be used to reveal the structural changes from different inner membrane leaflet models upon interacting with a group of antimicrobial lipopeptides with... -
Neutron Reflection from a Biomineralisation Glycosaminoglycan on Calcite
Here we aim to structurally characterise the formation of adsorbed monolayers of heparin on calcite to address how these species influence biomineralisation and the inhibition... -
Interaction of polypeptide with surfactant on the surface of water
This proposal constitutes part of our ongoing study towards understanding the adsorption of collagen based polypeptide and its interaction with ionic surfactants at the... -
Interfacial layer structure of lipopeptides adsorbed at the air/water interface
Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a... -
Interaction of keratin with surfactants studied by neutron reflection
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
NR study of surface adsorption of antibodies with and without non-ionic surfa...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in abinary mixture. However, we show in this work... -
Adsorption of bioengineered antibodies at the oil/water interface
Following our previous study of adsorption of Fc, Fab and the constituent mAb COE-3, we continue to explore how two bioengineered mAbs adsorb at the oil/water interface by... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,... -
Adsorption of hydrophobin at the oil/water interface
Following our previous study of adsorption of globular lysozyme and BSA, we continue to explore how another globular protein hydrophobin adsorbs at the oil/water interface by... -
The physics of detergency at low temperature: neutron reflection to reveal su...
Although surfactant detergency is well understood above 30 C, actions of surfactants below 30 C are not well established. In the era of energy saving and environment caring, we... -
Adsorption of Monoclonal Antibodies at the Solid/liquid Interface
We propose to use neutron reflection to study the interfacial adsorption of 2 novel bispecific therapeutic antibodies at the silicon oxide/water interface. To enpower each of... -
Interfacial adsorption of monoclonal antibodies and antigen binding
We have previously studied the adsorption of anti-beta-hCG at the hydrophilic silicon oxide/water interface and the subsequent binding by antigen hCG. We propose to extend this... -
Neutron Reflection Studies on Adsorption of Lauroyl-L-Carnitine (C12-L-Caniti...
Acyl L-Carnitines are a group of novel surfactants with attractive physical and biological properties associated with their head group charge features. This work proposes to use...