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Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form...
This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their... -
Structure-function studies of Replication Protein A and its complexes with DNA.
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
Adsorption of Fab and Fc from monoclonal antibody at the oil/water interface
Following our previous study of adsorption of globular lysozyme and BSA, we continue to explore how different globular proteins adsorb at the oil/water interface by neutron... -
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Mixed micelles of nonionic and metallosurfactants (P123/CTAF) as porogens of ...
Non-ionic/metallosurfactant (P123/CTAF) mixed micelles are used as templates for the hydrothermal synthesis of mesoporous ferrisilicate materials. It was hypothesized that... -
Effect of electrochemical control function and dopant anion on polyaniline fi...
We propose to determine the structures (polymer and solvent populations and spatial distributions) of polyaniline films deposited by different protocols. These involve different... -
Adsorption of hexadecyl maltoside on hydrophobised silica
The surface properties of alkylglycosides is of large interest as these non-ionic surfactants have proved to be versatile ingredients in manifold formulated products such as... -
Effect of high temperatures on the adsorption of benzotriazole onto copper/co...
Benzotriazole (BTAH) is a very effective corrosion inhibitor for copper and its alloys in both water and in oils. BTAH is introduced as a corrosion inhibitor in oil based... -
The use of magnetic contrast layers for neutron reflectivity to investigate n...
The search for new clever ways to deliver drugs, which often are not possible to dissolved in water, has lead to the development lipid based small particles. These particles can... -
Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bil...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
The structure of pharmaceuticals in aqueous solution: towards better drug sol...
The pharmaceutical industry has been described as being 'in a period of crisis' as the number of drug approvals relative to most major pharmaceutical companies Research and... -
QENS Analysis of Proton Diffusion in Functional Metal-Organic Frameworks
The development of new functional metal-organic frameworks (MOFs) as complex proton conductor is receiving increasing attention worldwide. We aim to develop new solid proton... -
Neutron Reflection at the Mica Water Interface
Mica is an exceptionally important mineral in surface science, which until now has been inaccessible by neutron reflection. Here we propose a novel attachment method unlocking... -
Hydration of Guanosine, G-quartets and G-quadruplex
Guanosine (GMP) is the ideal brick for controlled self-assembly of biocompatible materials, as it has the special ability to self-associate in water to form G-quartets (G4), and... -
Hydrated Surface Confinement Using Tethered Lipid Membranes Under Applied Ele...
Understanding the forces acting on macromolecular structures at surfaces is vital to a number of different branches of science and engineering, ranging from bio-fouling to... -
Muon Studies of Na-ion Diffusion in Novel Low-temperature Cathode Material: "...
The most important scientific problem to solve for our modern society is how to convert and store clean energy. We are currently on the verge for a general breakthrough in... -
Magnetic contrast reflectometry to resolve transmembrane potential effects on...
The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world.... -
Proton transport on metallic oxide nanoparticle surfaces
The surface of metal oxide nanoparticles are typically coated with layers of water that are strongly bonded to the surface. The properties of these water layers are... -
The dynamics of water and terephthalate in layered double hydroxide clay
In this proposal we would like to study the dynamics of interlayer species in hydrotalcite clay: (a) water and (b) terephthalate anions. In the case of water, the aim is to... -
Cryopreservation in biological systems: glutamine as a model system to study ...
Many living organisms have developed mechanisms that protect them from extremeenvironmental stresses such as freezing and pressure. One common mechanism involvesaccumulation of...
