127 datasets found

When nanoparticles enter a biosytem they rapidly acquire a protein corona. The nature of the outer part of this corona will determine the response of the biosystem to the...

Lung surfactant protein B, SP-B, is found at the air-water interface of the lung. A deficiency in SP-B at birth is known to be fatal. We have recently successfully studied the...

The proposed experiments will investigate conformational changes of the 18kDa translocator protein (TSPO) in a lipid bilayer using neutron reflectometry at the solid-liquid...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

Solventless protein liquids (SPLS) represent a novel form of biological matter. Recently we reported on the preparation and properties of a solvent-free liquid protein based on...

New detergents will increasingly rely on sustainable products and the use of enzymes will become ever more important. However, the process of destruction of stains (often...

Nanodiscs are self assembled complexes of phospholipids and a class of amphipathic helical proteins termed membrane scaffold proteins . The proteins and lipids self-assemble...

Protein-surfactant interactions at an interface play an important role for broad applications in the chemical, dairy, cosmetic and pharmaceutical industries. Rubisco is the most...

Hydrophobins are secreted fungal proteins in the form of small lipopetide biosurfactants. They are strongly surface active and self-assemble at interfaces and in solution. This...

We have recently shown that dense monolayers of PC can be assembled on gold surfaces using a new omega thiol PC from Avanti. This has two advantages over our previous methods....

A recent experiment has provided clear evidence for a large maximum in the adsorption just below the critical micelle concentration of the surfactant hexadecyl trimethyl...

Hydrophobins are secreted fungal proteins in the form of small lipopetide biosurfactants. They are strongly surface active and self assemble at interfaces and in solution. This...

Major technological and scientific challenges arise from the pressure to provide widely available and sustainable technologies for the societal requirements for health and a...

Our previous INS studies of ¿dry¿/hydrated apoferritin show that the hydrated protein undergoes a dynamical transition, Td, at 200K. Such behavior, first modeled by Doster et al...

Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation, crosslinking resulting in lack of orientation...

The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins...

Gene (nucleic acid) delivery to the cytosol or nucleus of a cell is, without the aid of a suitable delivery system, an inefficient process. Here the interaction of a defined...

The tripeptide glutathione (GSH) is present in cells at millimolar concentrations, and the ratio of GSH to glutathione disulfide (GSSG) is critical to cellular redox balance....

Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,...

We have a programme investigating the structure and function of protein scaffolds oriented on gold surfaces using sulfur chemistry for attachment. The aim is to direct the...