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Neutron reflectivity study of phase separation in polymer-drug thin films
Nearly 40% of new chemical entries are poorly water-soluble. Drug encapsulation into water-soluble polymers is an active research area owing to the ability of improving drug... -
Scaling Model for the adsorption of macromolecules at the oil-water interface
The aim of this proposal is the application of the scaling model for the adsorption of proteins at the oil-water interface. The adsorbed amount for a series of oils as a... -
Neutron reflectometry from surface of liquid 3He/4He film on silicon wafer
As it was predicted theoretically by Andreev at zero temperature for dilute 3He in 4He mixtures, 3He atoms will form a 2D Fermi liquid at liquid helium surface. Direct... -
The use of magnetic contrast layers for neutron reflectivity to investigate n...
The search for new clever ways to deliver drugs, which often are not possible to dissolved in water, has lead to the development lipid based small particles. These particles can... -
Interfacial adsorption of single alkyl chain PC surfactants (CnPmC)
We propose to investigate the interfacial adsorption of a series of water-soluble single chain PC surfactants using neutron reflection, focusing on assessing the effects of... -
Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bil...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
Neutron Reflection at the Mica Water Interface
Mica is an exceptionally important mineral in surface science, which until now has been inaccessible by neutron reflection. Here we propose a novel attachment method unlocking... -
Magnetic contrast reflectometry to resolve transmembrane potential effects on...
The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world.... -
How does oxidative damage change peptide membrane insertion?
The insertion of peptides and proteins into cell membranes is crucial for the functioning of cells, and also for the functioning of a variety of antibacterial reagents. Cells... -
Proteins of Different Size and Globular Stability Adsorbed at Oil/Water Inter...
In this work we explore how to use neutron reflection to study protein adsorption at the oil/water interface. Inter is preferred because we have built technical capability on... -
A study of hole injection efficiency for a model conjugated bilayer system
Polymer-based electronics have attracted huge interest due to their wide applicability to light emitting diodes, field effect transistors and photovoltaics. The aim of our... -
Investigation of the surface structure of anionic surfactants induced by the ...
This proposal is part of a major EPSRC (EP/GR065705) / Unilever funded programme to develop and control the spontaneous formation of surfactant multilayer structures at... -
Interactions between a polymer brush grown from a macro-initiator-modified sa...
We propose to make neutron reflectivity measurements of the weak polyelectrolyte, poly(dimethy amino ethyl methacrylate), grown from two different surface densities of initiator... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Spray-coating plastic solar cells: New materials & innovative processes for O...
We propose to study a range of new selenium containing lower energy gap organic photovoltaic materials deposited by spray coating using neutron reflectivity. The new materials... -
Neutron reflection from 3He layer adsorbed on liquid 4He surface
More than four decades ago A. F. Andreev predicted theoretically the existence of quantum states of 3He atoms on free surface of liquid 4He . In other words, at low... -
Membrane-stacking Properties of Mutant Myelin Proteins
Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further... -
Interaction of the nucleic acid, DNA, with a model biomembranes of varying ri...
In this experiment we aim to investigate, using neutron reflectometry in combination with contrast variation, the intermolecular interaction between the nucleic acid, calf... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,... -
Co-adsorption of monoclonal antibodies and non-ionic surfactants at the air/l...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in a binary mixture with protein. However, we show...