126 datasets found

In this proposal we investigate the adsorption of the key dispersant additive, sodium polyacrylate, used in colloidal systems using neutron reflection on aluminium oxide, with...

gemini surfactants are essentially two surfactants joined by a linking chain. We have extensively explored cationic geminis at the air/water interface and they exhibit a range...

As part of a project concerning the fate of nanoparticles in the body we have been studying the kinetic and competitive (or cooperative) aspects of protein adsorption. HSA is...

We propose to investigate the role of lateral phase separation on LPS insertion into model membranes and the effects of target membrane structure and composition. A comparison...

Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering...

AOT is also known to be very sensitive to the concentration and nature of counter-ions. When adding a sufficient amount of divalent salt to an AOT solution, a very strong Bragg...

We will use neutron reflectivity measurements of lipopolysaccharide (LPS) layers at the air-water interface to help develop a realistic mimetic for the periphery of bacteria...

We have been studying the formation of solid polymer-surfactant films at the air-solution interface formed from cationic surfactants with PEI. We wish to use the micelles...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

All solid surfaces in contact with biological systems form a protein corona and the nature of this corona determines the further response of the biosystem to that solid surface...

The objective of the present study is to investigate the interaction between PAMAM dendrimers and solid supported model biomembranes of high fluidity. These membranes consist of...

Bacterial LPS (endotoxin) is a key determinant of host/pathogen interactions. We propose to investigate the role of membrane lateral phase separation on LPS insertion into model...

PPO-PEO-PPO copolymer-based lubricant with extreme pressure or friction modifier additives has been introduced as boundary lubricant in metal forming. The Pluronic reverse...

Understanding the fundamental aspects of the surface adsorption and self-assembly of biosurfactant and biosurfactant / conventional surfactant mixtures is a major challenge for...

In this proposal we intend to investigate the intermolecular interactions in a mixed phospholipid/cholesterol monolayer at the oil-water interface using neutron reflectometry....

This proposal is part of a funded (CASE) project, aimed at understanding the delivery of benefit actives (perfumes) to interfaces and the development of new self-assembled...

Recently there has been a vast expansion in understanding about the interactions between oppositely charged polyelectrolyte/surfactant mixtures. The use of neutron reflectometry...

'Floating LSupported Bilayers' (FSB's) have become the 'standard' systems used for studying membrane systems using reflectivity at ISIS and other facilities. They are reliable,...

Exposure to ozone gas can cause inflammation of the airways and breathing difficulties. The initial reaction of ozone is thought to be predominantly with lipids present in the...