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Membrane perturbation and permeabilization by the lysosomotropic detergent MSDH
Lysosomes are subcellular organelles with acidic interiors (pH 3.5-5), containing enzymes that break down macromolecules and intracellular waste. Controlled release of lysosomal... -
Phase Separation in Organic Photovoltaic Cells
Organic photovoltaic (OPV) cells have the potential to be the basis of a renewable energy source that is inexpensive and portable. Current state-of-the-art solution-processed... -
Solution aggregation of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
The effect of heating on Gelator Solutions
Low molecular weight gels are formed by the self-assembly of small molecules into fibres that entangle to form a matrix. Hydrogels are an important class, as these are typically... -
Investigating the Influence of Polymer Properties on Cyclic Peptide-Polymer C...
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes (CPNTs). The conjugation of polymers to these peptides renders the... -
Structural characterization of a series of polymer-protein conjugates for chr...
Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for... -
Polymer-surfactant adsorption at the oil-water interface
Polymer-surfactant stabilised emulsion droplets are a potentially exciting route for micro-encapsulation of volatile agents (such as perfumes, flavours and many other benefit... -
Probing the Kinetics of Assembly and Triggered Dispersion of Peptide-Function...
Peptide-functionalized nanoparticle (NP) aggregates have significant potential as biosensors (for specific enzymes) due to their high sensitivity, modular design and simple... -
The effects of molecular weight on the structure of non-covalent polymer ther...
Polymer therapeutic describes polymeric drugs, polymer-drug conjugates, polymer-protein conjugates, polymeric micelles to which drug is covalently bound, and multicomponent... -
Do hydrotropes stabilize, or destabilize, micelles?
The aim is to investigate and understand interactions of hydrotropes (primitive amphiphiles) with a new range of industrially important non-ionic surfactants, alkyl-capped... -
Generation of 3D-networks by mixing inexpensive HC-polymers, amphiphiles, and...
For the last two decades, many polymers have been tested to increase CO2 viscosity for enhanced oil recovery using CO2 (CO2-EOR). Unfortunately, conventional HC-polymers were... -
The effect of anionic lipid unsaturation on the interaction with cytochrome c
While peripheral membrane protein-lipid interactions were originally considered to be solely electrostatic in nature, it is now accepted that they encompass more complicated,... -
SANS studies of imprinted nanogels: evaluation of a possible relationship bet...
The aim of the project is to use Small Angle Neutron Scattering (SANS) to determine the particle sizes and the internal shell dimensions of the nanogels as a function of the... -
Probing membrane localisation of molecular rotors (SANS)
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Salt effects on gelation of oxidised cellulose nanofibrils with nonionic surf...
Our group has been studying partially oxidised anionic cellulose (AC) nanofibrils which form gels in the presence of moderate salt concentrations and with anionic surfactants.... -
Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form...
This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their... -
Investigation of phase diagrams of polysaccharides
This project concerns fundamental and strategically important research underlying the development of new drug delivery vehicles. We propose to sample phase diagram of... -
Metallomicroemulsions - a new class of supramolecularly organised metal ions
Incorporation of d- or f-block metals into ligand systems that renders a metal complex surface active or drives its partitioning into surfactant phases enables the localisation... -
Aggregation behaviour in solution of cationic conjugated polymers and oligomers
We extend previous work on aggregates formed by cationic conjugated oligomers in water with surfactants and... -
Photo-reactive surfactants for nanoparticle generation
The aim is to employ contrast variation CV-SANS to investigate structure in novel systems used to generate metal-containing nanoparticles on organic solvents by UV irradiation....
