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Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
The effect of membrane fluidity on the interaction of antimicrobial proteins ...
Protein-lipid\membrane interactions are fundamentally important to biological processes. We have examined the role protein hydrophobicity in protein-membrane interactions... -
Structure of Confined Mucin Films
Nowadays, a significant research effort is devoted to understand and mimic biological lubricants which, in contrast to most man-made lubricants, are based on water. It has been... -
Anionic surfactant induced desorption of cationic surfactants from anionic su...
In this proposal, we request beamtime to study the unexpected behaviour of a strongly bound bilayer of the cationic surfactant didodecyldimethylammonium bromide on the anionic... -
Adsorption of magnetic surfactants
Surfactants responsive to pH, temperature, CO2, and light are known, however, our recent work has shown, for the first time surfactants that are magneto-responsive, and also... -
Effect of glycolipids with therapeutic potential on phase behaviour of model ...
alpha-galactosylceramide (a-GalCer) can activate an immune response through a protein-mediated cell signalling event. The effect of a-GalCer on local membrane structure is... -
Organic Additives Adsorption at the Steel-Paint Interface and Its Effects on ...
Numerous additives have been added to paints and coatings to improve adhesion, and prohibit corrosion if the substrate is reactive to its surrounding environs. The adsorbates in... -
A study of the role of divalent cations in the stability of smooth LPS in out...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaires disease. It is important as; a barrier to antibiotics & the site of... -
Determination of Organic Friction Modifier conformation under shear
Engine oils act to lubricate and protect moving parts in an engine. They act to reduce friction and reduce emissions. A major class of friction reducing additives are organic... -
Depth profiles in bulk heterojunction films containing low-molecular weight o...
Neutron reflectivity will be used to investigate the composition in the direction perpendicular to the substrate for films of blends of electron-donor... -
Interaction of Low Density Lipoproteins (LDL) with Model Mammalian Cell Membr...
Atherosclerosis and subsequent clinical complication is one of the biggest killers in the western world, with a death toll reaching 16.7 million deaths per year. Although many... -
Warm Polar Cloud Chemistry: Can the Halogen "explosion" effect cloud droplet ...
The oxidative processing of pollutants in Polar clouds affects droplet size and optical properties. Polar clouds contain naturally occurring organic lipids forming organic films... -
Lipid exchange between high density lipoprotein (HDL) and model phosphatidylc...
Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related... -
Neutron reflectometry of an atopic dermatitis stratum corneum skin model
Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting up to 20% of children and 3% of adults, resulting in significant reduction in quality of life and costs... -
Adsorption of hydrophobin at the oil/water interface
Following our previous study of adsorption of globular lysozyme and BSA, we continue to explore how another globular protein hydrophobin adsorbs at the oil/water interface by... -
Modelling the Intracellular Lipid Shuttling Mechanism of Non Specific Lipid T...
Previously we have examined the interaction of barley non-specific lipid transfer protein (nsLTP1) with OTS and lipid monolayers at the solid/liquid interface. Examining the... -
Structure of Confined Albumin Layers
In the context of a project in collaboration with ISIS that focuses on structural studies under mechanical confinement, with a specific focus on biological lubricants, the... -
Understanding the antimicrobial activity of the salivary protein Histatin 5
The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis... -
Adsorption of an Anionic Surfactant on Anionic Surfaces in the Presence of Po...
In this proposal, we request beamtime to study the very unexpected adsorption behaviour of the surfactant bis(2-ethylhexyl) sulfosuccinate potassium and ammonium salt (K(AOT)... -
Neutron reflectivity of water soluble conjugated polymer/surfactant films
Water-soluble conjugated polymers (WSCP) are an important class of materials which have received great attention as active materials in optoelectronic devices and in biosensing....
