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Understanding the Affect of Lipid Tail Saturation on Anaesthetic Interaction ...
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
Bilayer modification and charge screening by simple ions
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported DPPC bilayer films. At low concentrations... -
Interaction of Surfactant with Model Lipid Membranes: Influence of Surfactant...
Skin becomes a target of drug delivery because the transdermal routes are non-invasive, can be self-administrated, improve patient compliance and can provide release for long... -
Designing a model of the epithelial apical plasma membrane to facilitate stud...
This beam time application aims to provide preliminary data to support a wider research programme and grant application that will seek to develop a sophisticated and effective... -
Purothionin binding to model fungal lipid membranes
Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of... -
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Probing the interactions of chitosan with lipid bilayers to elucidate its ant...
Chitosan is a linear polysaccharide that is biocompatible and biodegradable. Chitosan has a number of unique chemical and biological features including its cationic nature and... -
A comparative NR study of interaction of short designed antimicrobial peptide...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Oxidation of gram-negative cell-wall proxy with OH radicals - kinetics and me...
Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. We very recently oxidised... -
Electrostatic Interactions between Floating Bilayers and Thiol Coated Interfa...
Bilayers which float below a self-assembled monolayer (SAM) coated solid support represent one of the most advanced membrane mimetics. Recently (RB 1720155) we assessed the... -
The Formation of Ion Channels in Phospholipid Bilayers by Puroindoline-a
Puroindolines are basic, cysteine rich proteins of ~13KDa, which have attracted significant interest due to their role in determining the endosperm texture of Wheat and seed... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
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