43 datasets found

Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading to interfacial adsorption and solution nano-aggregation....

Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug...

Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel...

This proposal relates to the structural studies of Di-stearoyl and di-palmitoyl Polyethylene glycol derivates as a function of the PEG head group at the air-water and the...

We will use neutron reflectivity measurements of lipopolysaccharide (LPS) layers at the air-water interface to help develop a realistic mimetic for the periphery of bacteria...

Antimicrobial peptides are small, usually alpha-helical peptides that kill cells by disrupting the cell membrane. Recently, we have been studying a simple 'designed'...

The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects....

Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by...

Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular...

Cell-nanoparticle interactions are complex, involving several specific and non-specific intermolecular forces between a wide range of particulate and molecular species . There...

Oxidation of membrane lipids by Reactive Oxygen Species, ROS, in cells may impact ageing, cell apoptosis and cancer. We propose to use our skills obtained studying the oxidation...

Surfactants have been widely used in cosmetics, detergents and pharmaceutical industries. These applications are always accompanied by surfactant-induced skin irritation which...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

Molten chocolate is a semi-solid suspension of (mostly) sugar, but also cocoa and milk solids in oil. In order to allow the sugar grains to flow past each other, either when the...

In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed...

Purothionins are a family of cationic cystiene rich plant defence proteins which have been shown to have a wide spectrum of activity due their ability to permeate cellular...

Oxidation of atmospheric aerosol can produce cloud condensation nuclei capable of changing the reflectivity and lifetime of clouds. The oxidation of organic film on atmospheric...

The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface....

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Styrene-Maleic Acid Lipid Particles have a number of attractive...