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Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the... -
Investigation of the interactions of perfluoroalkyl substances with model wor...
Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
Defects in the Core Oligosaccharide in Gram Negative Bacterial Outer Membrane...
The outer membrane of Gram negative bacterial is an effective barrier for many harmful agents. We have been developing and testing advanced models of the Gram negative bacterial... -
The structure and orientation of the Bam complex in the Gram-negative outer m...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterialsurvival, from providing basic physiological functions, to aiding virulence and... -
Charged nanogels and their ability to penetrate model lipid membranes
Drug delivery through the skin is an important route for administration of therapeutic agents. However, the outermost layer of the skin, the stratum corneum provides a... -
Understanding anaesthetics: Ethanol partitioning into lipid membranes, effect...
Ethanol plays an important role in the human metabolism. It is in particular known to act as a drug enhancer by increasing trans-membrane permeability, and as an anesthetic.... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Assembling floating, very sparsely tethered, protein-lipid bilayers.
We have recently used Polref in to measure the assembly of tethered floating lipid bilayers. These are useful models of biological membranes in which a phospholipid bilayer is... -
SANS Studies of Novel Internally Stabilised Liposomes
Internally supported liposomes (ISLs) are composed of polymeric spheres enclosed by liposomes. Although very little research has been done on ISLs, understanding their... -
Supermirror Guide testing
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