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Whole genome sequencing of amphotericin B adaptors in Candida parapsilosis #1...
Candida parapsilosis clinical isolate #12584 was exposed to 3µg/ml and 4µg/ml amphotericin B. Randomly 30 adaptors (3 µg/ml) and 99 adaptors (4 µg/ml) were sequenced. -
Candida parapsilosis SR23 (CBS 7157) genome sequencing
Candida parapsilosis is a fungal human pathogen. In this project, we determined a high-quality genome sequence of the strain SR23 (CBS 7157). -
Triazole evolution of C. parapsilosis influences stress response and virulenc...
Antifungal resistance of Candida parapsilosis to azole is an increasing problem worldwide. In contrast with other Candida species, there is less knowledge on resistance... -
The APSES Transcription factor Efg1 regulates a novel phenotype switch in Can...
We use ChIP-seq to identify the targets of Efg1 in Candida parapsilosis. We show that Efg1 binds to 502 promoter regions, including 70 potential transcription factors or... -
The APSES Transcription factor Efg1 regulates a novel phenotype switch in Can...
In Candida albicans the Efg1 transcription factor (a member of the APSES family) is an important regulator of hyphal growth, and of the white-to-opaque transition. In contrast,... -
Linked machine learning models improve species classification of fungi when u...
The increased usage of long read sequencing has not been matched with publicly available databases suited for error-prone long reads when applied to metabarcodes. We address... -
CRISPR-Cas9 editing induces Loss of Heterozygosity in the pathogenic yeast Ca...
Genetic manipulation is often used to study gene function. However, unplanned genome changes (including Single Nucleotide Polymorphisms (SNPs), aneuploidy and Loss of... -
Whole genome sequencing of tunicamycin adaptors in Candida parapsilosis
We exposed Candida parapsilosis clinical isolate #12108 to YPD plate supplemented with 8µg/ml of tunicamycin. We randomly selected 18 adaptors. We did sequencing of these adaptors. -
Whole genome sequencing to study of pathogenic Candida strains
Aim of this project is to identify biomarkers associated with persistance of Candida strains in the host and with virulence/pathogenicity of the different strains -
MJ20220527135-MJ-R-20220808022-Eukaryotic transcriptome sequencing of 9 samples
RNA Sequencing was used to calculate gene expression comparing the difference among different groups after NAC/MF administration (CP-con vs CP-NAC CP-con vs CP-MF). -
Sequencing of azole-resistant isolate of Candida parapsilosis
The genome sequences of Candida parapsilosis BC014RPSC and BC014 strains were sequenced using Illumina, to identify Single Nucleotide Polymorphisms. -
Role of Hac1 in unfolded protein response in Candida parapsilosis
Investigation of the role of HAC1 using transcriptional profiling of Candida parapsilosis treated with 5 mM dithiothreitol Gene expression of wild type and hac1 deletion strains... -
Diversity of Candida species in bloodstream infections compared to gut and sk...
This study characterized the diversity of Candida present in patients with candidemia, comparing bloodstream isolates to those found at other body sites. We carried out whole... -
RNA-seq of Candida parapsilosis CLIB 214 (CBS 604) grown on different hydroxy...
Candida parapsilosis CLIB 214 (CBS 604) was grown on synthetic media containing hydroxyaromatic compounds as a sole carbon source. The cells cultivated in medium containing... -
RNA-Seq of healthy human dendritic cells after challenge with four different ...
Dendritic cells from three healthy human donors were cultured in the presence or absence of either Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans or Candida...
