-
Antibiotic paths through the bacterial outer membrane: The strange case of va...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Orientation of an Antimicrobial Peptide in Eukaryotic and Prokaryotic Membranes.
Antimicrobial peptides are small, usually alpha-helical peptides that kill cells by disrupting the cell membrane. Recently, we have been studying a simple 'designed'... -
The structure and orientation of the Bam complex in the Gram-negative outer m...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterialsurvival, from providing basic physiological functions, to aiding virulence and... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
A complex model of the bacterial outer membrane containing oriented proteins ...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire¿s disease. It is important as; a barrier to antibiotics & the site of... -
Comparative Interaction Studies of Antimicrobial Agents on Floating Asymmetri...
The outer membrane (OM) of Gram-Negative bacteria (GNB) is an asymmetric structure which contains complex lipids known as lipopolysaccharides (LPSs) on the outer surface. LPSs... -
Comparing the assembly of LPS into model Outer Membranes by Langmuir-Blodgett...
We have recently created and published a model of the Gram negative bacterial Outer membrane (OM) which recreates many aspects of its behaviour and will improve our ability to... -
Assembling floating, very sparsely tethered, bilayers.
The cell membrane is a very important structure in biology and many laboratory based model systems have been developed to study it using biophysical techniques. Our particular... -
The Interaction of Grp1 with Membranes Containing Signalling Phospholipids
This dataset has no description
-
Defects in the Core Oligosaccharide in Gram Negative Bacterial Outer Membrane...
The outer membrane of Gram negative bacterial is an effective barrier for many harmful agents. We have been developing and testing advanced models of the Gram negative bacterial... -
Designing a model of the epithelial apical plasma membrane to facilitate stud...
This beam time application aims to provide preliminary data to support a wider research programme and grant application that will seek to develop a sophisticated and effective... -
Optimisation of Experimental Conditions for the Study of Anionic Self-Assembl...
We have developed a Self-assembled floating supported membrane sample system comprised of unsaturated phospholipid bilayers held ~1nm from a PEGylated charged alkane thiol SAM... -
Quantifying antibiotic resistance using bacterial model membranes
The Gram negative bacterial outer membrane protects the bacterium from toxins such as antibiotics and is partially responsible for the rapid rise in antibiotic resistance in... -
Free Floating Higher Plant Membrane Mimetics
We have engaged in a long term effort to build accurate bio-mimetic systems for complex structural biology studies. Recently, we have found that thiolalkylamidealcohol... -
Do cardiolipins play a role for the mode of action of antimicrobial peptides?...
Antimicrobial peptides (AMPs), also called host defense peptides, are part of the innate immune system of essentially all species, from bacteria themselves to mammals to protect... -
Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bil...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
The structure and orientation of the Bam complex in the Gram-negative outer m...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterialsurvival, from providing basic physiological functions, to aiding virulence and... -
Assembling Biomimetic layers on monolayers of Gold Nanoparticles
Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can... -
A comparative NR study of interaction of short designed antimicrobial peptide...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Assembling floating, very sparsely tethered, bilayers.
The cell membrane is a very important structure in biology and many laboratory based model systems have been developed to study it using biophysical techniques. Our particular...
