-
The SAGA coactivator complex acts on the whole transcribed genome and is requ...
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes.... -
Identification of genes involved in high-production of threonine in Saccharom...
The goals of this project are to identify genes responsible for high-production of threonine in Saccharomyces cerevisiae and clarify the mechanism. -
Translation initiation site profiling reveals widespread synthesis of non-AUG...
Genomic analyses in budding yeast have helped to define the foundational principles of eukaryotic gene expression, but have systematically excluded specific classes of potential... -
Saccharomyces cerevisiae Raw sequence reads
Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses -
Mutational_Signatures_in_the_YKO_collection
This project is being carried out through a Strategic Award from the Wellcome Trust to Steve Jackson, Mike Stratton, Peter Campbell, Serena Nik-Zainal and others. This grant is... -
Study of ribosome dynamics after eIF5A depletion in budding yeast
eIF5A is an essential translation elongation factor present in all eukaryotes, and the only known protein to follow a post-translational modification called hypusination. Here,... -
Transcriptional sequencing of engineered yeast
To identify the effect of different genetic manipulation on gene transcription in engineered yeast. Transcriptomics analysis was performed. -
Rapid screening of TCR-pMHC interactions by YAMTAD system
By expressing TCR and pMHC on the surface of S. cerevisiae MATa and MATalpha haploid cells, the Yeast Agglutination Mediated TCR antigen Discovery system (YAMTAD) was designed... -
Yra1-bound R loops cause orientation-independent transcription-replication co...
R loops are an important source of genome instability largely due to its negative impact on replication progression. Yra1/ALY is an abundant RNA-binding factor conserved from... -
Hop1 ChIP-Seq data in S. cerevisiae
Hop1 is a meiotic chromosome axis protein, critical for meiotic recombination. To determine Hop1 binding sites in wild type and hop1 mutant strain during meiosis, we performed... -
Sequencing of whole genomes of yeast strains lacking N-terminal part of DNA P...
In order to study the mechanisms replication resilience in eukaryotes, we have sequenced genomes of yeast mutants emerging on the background of partial POLE deletion. -
Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3...
Dpy-30 is a regulatory subunit controlling the histone methyltransferase activity of the KMT2 enzymes in vivo. Paradoxically, in vitro methyltransferase assays revealed that... -
CRISPRiSeq raw data
Sequencing data for amplicon sequencing of guide locus during pooled fitness assay in five growth conditions for ~17,000 double CRISPRi yeast strains. Fitness data is used to... -
Genetic and pharmacological evidence for kinetic competition between alternat...
PAT-seq approach was used to determine changes to 3'UTR length in yeast upon mutation of NNS subunits Nrd1 (nrd1-5), Nab3 (nab3-11) and Sen1 (sen1-1) compared to wild type cells... -
Complex Mutation Profiles in Mismatch Repair and Ribonucleotide Reductase Mut...
Targeted sequencing revealed complex mutation profiles in yeast strains that have elevated dNTP levels paired with deletions in mismatch repair genes. -
Jean-Talon beer strain
Sequencing of an archeological yeast isolate sampled from the site of the Jean-Talon Intendant's palace in Old Quebec, Canada -
yeast gene expression under 800 mM or 0 mM NH4Cl treatment.
In order to explore the mechanism of cells responding to NH4Cl, we conducted transcriptome analysis of the changes in genes under NH4Cl stress.Yeast cells treated with 0 mM and... -
Transcriptome analysis of Drrp6 and Drrp6, sen1DNIM by RNAseq
Pervasive transcription is a widespread phenomenon leading to the production of a plethora of non-coding RNAs (ncRNAs) without apparent function. Pervasive transcription poses a... -
High resolution mapping of modified nucleobases in DNA using excision repair ...
Data from Excision-seq experiments to map deoxyuridine and pyrimidine dimers in S. cerevisiae and E. coli Overall design: For uracil mapping in pre-digestion Excision-seq,... -
Classifying pathogenic variants in amyloid beta using intramolecular genetic ...
Changes in the amino acid sequences of proteins cause thousands of human genetic diseases. However, only a subset of variants in any protein is typically pathogenic, with...