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Part A: Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic l...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
Surface adsorption of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
The hydration and ordering of lamellar block copolymer films prior to the for...
For polymer vesicles to act as effective molecular delivery systems we must efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron... -
Monitoring the formation of surface-enriched PbI2 in atmospherically treated ...
Metal halide perovskites have enabled remarkable advancements in low-cost, high-performance optoelectronics, however their performance potential is restricted by an incomplete... -
Role of apolipoprotein E variant on HDL interactions at model cell membranes
Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate... -
Interaction of lignosulphonates with model surfactant systems by neutron refl...
With the biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, it is vital that the Home and Personal Care industry... -
D2O Vapour Diffusion at the Air Water Interface
A theoretical estimate of the H/D exchange rate for an open trough (e.g. D2O in ambient atmosphere, 50% relative humidity) yields an amount of exchanged liquid of the order of... -
Electrostatic Control of Protein Adsorption under Re-entrant Conditions
Protein adsorption is a process relevant in many research fields such as biology, medicine and food processing. Its mechanism is influenced by many parameters. Our group has... -
Investigation of the translocation potential of therapeutic macromolecules in...
Exosomes are released by cells are responsible for cell-cell communication of macromolecules and the development of disease such as cancer. These nanoparticles are loaded with... -
Neutron Reflection study characterising the fundamental structure and composi...
Understanding the plant wax-surfactant interaction process and the influence of surfactants upon the wax transport properties is crucial for the development of more efficient... -
Understanding the interfacial behaviour of bile salts to better engineer lipi...
The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on fat digestion. Neutron reflectivity (NR) is the... -
Tackling antimicrobial resistance: structural study of the Annexin A5/Lipopol...
Antimicrobial resistance is a global epidemic and has occurred due to a widespread antibiotic overconsumption. Gram negative bacteria, such as P. aeruginosa (leading cause of... -
More than the sum - oxidation behaviour of mixed fatty acid monolayers
Single molecule thin films of various surface-active species are found on the surface of water bodies from the sea down to microscopic spray droplets. These films affect the... -
How do Surfactants Interact with Complex Monoclonal Antibodies at Oil/Water I...
Heavily bio-engineered monoclonal antibodies (mAbs) are an increasingly important trend in the biopharmaceutical industry. However, these mAbs are often destabilised by the... -
Competitive adsorption in hydrophobin-surfactant mixtures
Hydrophobins are small compact secreted fungal proteins which are strongly surface active and adhere to both hydrophobic and hydrophilic surfaces. Their strong surface activity... -
Designing a model of the epithelial apical plasma membrane to facilitate stud...
This beam time application aims to provide preliminary data to support a wider research programme and grant application that will seek to develop a sophisticated and effective... -
Dynamic Surface excess concentration of pH-responsive chelating surfactants
This study will examine a process of slow dynamic change in surface excess of a unique pH-responsive chelating surfactant at the air/liquid interface that occurs over a period... -
Depth Profile of High Hole-Mobility Polymer/Fullerene-derivative Bilayers for...
Advantages of using organic materials as the active layer in photovoltaics include their suitability for low cost and large area processes and their mechanical flexibility. In... -
Kinetics and growth mode of aggregation phenomena inside polymer brushes
We will use time-resolved specular neutron reflectivity measurements to follow the in-situ growth of polymer brushes by surface-initiated ATRP. This will enable us to determine... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,...
