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Tuneable Adsorption of Soft Colloids on Model Biomembrane
Understanding how nanoparticles interact with lipid bilayers will potentially have high impact on the development of new drug delivery systems, and on the investigation of their... -
Using the nano discs approach at surfaces to determine the relation between s...
Membrane bound proteins continue to be to date the most elusive molecules in nature, since they are only functional in the lipid bilayer. We have developed a method to study... -
Seizing Membrane Proteins - Cytochrome P450 Reductase in Nanodiscs
This proposal seeks to shed light on the functional and structural characteristics of a specific membrane protein - cytochrome P450 reductase (abb. POR) - part of the cytochrome... -
Interaction of Low Density Lipoproteins (LDL) with Model Mammalian Cell Membr...
Atherosclerosis and subsequent clinical complication is one of the biggest killers in the western world, with a death toll reaching 16.7 million deaths per year. Although many... -
NR characterization of aquaporin-containing silica-reinforced supported PC bi...
Despite the abundancy of sea water there are 663 million people that lack access to safe drinking water. This is due to excessive energy consumption and hence cost coupled to... -
The use of lipid sponge-like nanoparticles as carriers for macromolecules and...
Conventional ways to administer and deliver drugs have reached its limitations. These methods can be still used for small and simple molecules. However, new carriers have to be... -
The use of lipid sponge-like nanoparticles as carriers for macromolecules and...
Biological membranes do not only occur as planar bilayer structures, but bilayers have also been shown to, depending onthe lipid composition, curve into intriguing 3D... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
Interplay of apoptosis regulating Bcl-2 proteins at mitochondrial membranes u...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). This pathway is a major regulator in cell... -
Role of apolipoprotein E variant on HDL interactions at model cell membranes
Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate... -
Effect of temperature on the structure of model wax films as studied by neutr...
Cuticular wax films protect plants by mediating water and nutrient transport from the environment. Surfactant is a key ingredient in agrisprays that can promote the uptake of... -
Controlling Protein Adsorption on Silicon with Trivalent Ions: Understanding ...
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Interaction of human dihydroorotate dehydrogenase with ubiquinone in model li...
Human dihydroorotate dehydrogenase (DHODH) is a membrane-bound enzyme of clinical interest and a well-validated drug target for e.g. rheumatoid arthritis and multiple sclerosis.... -
Interactions of modified clupeines with Gram-negative model bilayers
Clupeine is isolated from herring and is an example of a protamine, which are cationic antimicrobial peptides occurring in the sperm cells of some fish. Protamines are active... -
Investigation of the interactions of perfluoroalkyl substances with model wor...
Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable... -
Exploratory SERGIS/SESANS study of Si nanowires
Nanowires are increasingly being used in life science as nanometer probes and interfacing with cells. In our work we focus on the interaction between nanowires and a... -
The Interactions of Blood Components with Models of the Gram Negative Bacteri...
One of the major challenges in the fight against antimicrobial resistance is the development of antimicrobial compounds that selectively disrupt bacterial membranes and leave... -
Model anionic/non ionic surfactant adsoption at the interface below room temp...
An experiment performed on INTER last year found extreme non ideal mixing between C12E8/SLES3 at the air water interface: this feature became more extreme as the temperature... -
Self-assembling antimicrobial peptides: interactions with model lipid membranes
We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust... -
Understanding the antimicrobial activity of the salivary protein Histatin 5
The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis...
