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The internal structure of high internal phase volume nanoemulsions
Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as... -
SANS studies of antimicrobial peptide-surfactant aggregate structures
The theta-defensins are small, arginine rich peptides involving 18 residues arranged with N-to-C-terminal main chain cyclisation stabilised by three disulphide bridges with... -
Chipir commercial access: Cisco Systems, Inc. in Mar 2-5
Chipir commercial access: Cisco Systems, Inc. -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Adsorption of liquid crystal nanostructured particles to model hydrophilic an...
Cubosomes and hexosomes are particles with internal liquid crystal structures of the bicontinuous cubic or reverse hexagonal nanostructures respectively. The nanostructure... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Solid dispersions: influence of polymer conformation on drug dissolution
Solid dispersions are molecular mixtures of drug and excipient, usually a polymer. The use of solid dispersions is of interest as a means of improving the rate of solution (i.e.... -
Effect of drug structure on solubilisation in a range of surfactant micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the structure of a surfactant molecule, the micelles it forms in solution,... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Water-free phospholipid-based microemulsions
Small angle neutron scattering (SANS) studies in combination with contrast variation will be used to determine the molecular architecture of... -
Effect of lipid oxidation on raft formation using contrast variation SANS
The very heterogeneous, but non-random, arrangement of lipids and proteins in cell membranes are of major scientific interest and led Simons and Ikonen to propose that ¿rafts,¿... -
Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
Microdomains in model membranes using contrast variation SANS
In the present proposal small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of... -
Probing the kinetics of the formation of lipid, peptide and DNA/siRNA complex...
Complexes prepared from cationic, dichain lipid (L) vesicles, positively chargely targeting peptides (P) and negatively charged DNA (D) or siRNA (R), known as LPDs and LPRs... -
Evolution of raft formation over time using contrast variation SANS
Small angle neutron scattering will be used in combination with contrast variation as a non-invasive method to detect the presence and size formation of lipid microdomains or... -
Effect of drug structure on solubilisation in a range of surfactant micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the structure of a surfactant molecule, the micelles it forms in solution,... -
Effect of lipid oxidation on raft formation using contrast variation SANS
The very heterogeneous, but non-random, arrangement of lipids and proteins in cell membranes are of major scientific interest and led Simons and Ikonen to propose that ¿rafts,¿...
