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DPPC bilayer oxidation by aqueous singlet oxygen
Oxidation of membrane lipids by Reactive Oxygen Species, ROS, in cells may impact ageing, cell apoptosis and cancer. We propose to use our skills obtained studying the oxidation... -
Organization of mitochondrial membranes upon oxidative stress: Impact on apop...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
New Approaches to Producing Floating Supported Bilayers
The complex sample environment needed for floating supported bilayers has often led to a need to constantly redevelop the system to improve reproducibility. Here we plan to... -
Stability and protein binding interactions of a free standing model bacterial...
We recently improved free standing bilayers using a thiolipid layer on gold which also permits magnetic contrast reflectometry. One use for this system is to contribute to our... -
Penetration and reaction of hydroxyl radical into organic films at the air-wa...
The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects.... -
Floating Bilayers Deposited on Au / Fe Surfaces
There is currly great interest in the use of neutron reflection to study model bilayers. We have produced a model membrane system that is strongly associated with the substrate,... -
Nanostructure of reverse osmosis polymeric membrane for water filtration
Seawater desalination process with reverse osmosis membrane has been widely used to supply high quality water. Over the past decades, despite considerable performance... -
Non fullerene organic photovoltics
Organic solar cells (OPVs) are photovoltaic devices that can convert the energy from sunlight into electricity and have attracted much attention as a viable green energy source... -
Orientation of an Antimicrobial Peptide in Eukaryotic and Prokaryotic Membranes.
Antimicrobial peptides are small, usually alpha-helical peptides that kill cells by disrupting the cell membrane. Recently, we have been studying a simple 'designed'... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
The effect of bilayer rigidity on the interactions with perfluoroalkyl compounds
Perfluoroalkyl substances (PFASs) are used extensively in industrial products although have been identified as emerging pollutants accumulating in wildlife and environment.... -
Interaction of thermo-responsive deutrated nanogels with lipid monolayer at t...
Drug delivery through skin is an important delivery route. However, the outermost layer of the skin provides a formidable barrier to dermal absorption and penetration for... -
Investigation of the interactions of perfluoroalkyl substances with model wor...
Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable... -
Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Re...
Floating bilayers are supported phospholipid membranes, which are minimally constrained by the influence of the substrate, and therefore considered to be more realistic than... -
Interaction of Antimicrobial Silver Nanoparticles with Eukaryotic and Prokary...
Silver nanoparticles have been shown to have strong antimicrobial effects against many organisms, including those resistant to conventional antibiotics. However, the exact... -
Understanding the Affect of Lipid Tail Saturation on Anaesthetic Interaction ...
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
Model biomembrane dendrimer interactions
The objective of the present study is to investigate the interaction between PAMAM dendrimers and solid supported model biomembranes of high fluidity. These membranes consist of... -
Surfactant Segregation in Plasticised PVA
PVA film is widely used as a non-toxic water soluble polymer. This proposal relates to its use in unit dose detergent pouches where plasticised PVA film stores a concentrated... -
The Interaction of Grp1 with Membranes Containing Signalling Phospholipids
This dataset has no description
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A complex model of the bacterial outer membrane containing oriented proteins ...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire¿s disease. It is important as; a barrier to antibiotics & the site of...
