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pH-control of swelling and charge neutralization of thin hydrogel films
Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is... -
Antimicrobial Mechanisms of Model Biocides via Their Interaction with Lipopol...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Do hydroxyl radicals penetrate the organic monolayer at the air-water interface?
The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects.... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
A comparative NR study of interaction of short designed antimicrobial peptide...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Interaction of a pH-sensitive Polymer with a Model Lipid Membrane in the Form...
This SANS experiment was proposed by 4 PhD students from 3 different institutions in a Marie-Curie Training Network. They are all in the second year of their PhD and their... -
Understanding the interaction between antimicrobial peptide-loaded lipid part...
The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an... -
NR Investigation of Structural Basis Underlying Synergistic Binding of Lipope...
In this part of the proposed work, we wish to explore how antibiotics and antimicrobial peptides interact with model lipid bilayers in the form of a supported lipid bilayer,... -
Conformational study of subtilin/lipid-II binary membrane complex formation.
Resistance to antibiotics is a major problem for the clinical management of infectious diseases, which are still a major cause of human mortality worldwide and resistance... -
A model of the bacterial outer membrane containing both Outer Membrane Protei...
We have recently improved the stability and coverage of free standing bilayers (FSB) by the use of a supporting thiolipid layer on gold. The system has been investigated on... -
Structural evidence from SANS on self-assembly of antimicrobial lipopeptides ...
Previous studies have demonstrated that the de novo designed antimicrobial lipopeptides can self-assemble to beta-sheet nanofibers, but can transform to alpha-helical monomers... -
Purothionins Perturb Bacterial Membrane Function via Ion Channel Formation
Purothionins are a family of cationic cystiene rich plant defence proteins which have been shown to have a wide spectrum of activity due their ability to permeate cellular... -
Adsorption of NHE1 intracellular domain on lipid bilayers
Recently the intracellular domain (ICD ) of the Na+/H+ exchanger isoform 1 (NHE1), is a transmembrane protein, has been identified as an intrinsically disordered protein.... -
Floating Bilayer Mimics of the Gram Negative Bacterial Outer Membrane
The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will... -
The Interaction of Grp1 with Membranes Containing Signalling Phospholipids
This dataset has no description
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The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Investigation of PVC plasticizers on phospholipid monolayers
Plastic bags are used as containers for storage of donated blood. These bags are typically made out of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into... -
NR Study of Selective Binding of a-Helix Antimicrobial Peptides onto Bacteria...
In this work we will explore how to use PolRef to study the binding of our rationally designed peptide amphiphiles onto floating lipid bilayers mimicking G- bacterial and red... -
Arctic Cloud Chemistry: Can the Halogen "explosion" oxidize material at air-w...
The Arctic climate is strongly influenced by clouds. The oxidative processing of pollutants in Arctic clouds affects droplet size and optical properties, important climatic...
