The role of chirality on polymeric membrane lytic activity

DOI

The human body has a well developed membrane chemistry which allows transport of fluids and salts whilst preventing other molecules and harmful agents from penetrating the cell. Transport of drugs and other benefit agents relies on developing agents which behave like the constituents of the cell membrane but then release their payload on entering the cell. The aim of this proposal is to establish how modifying the chemistry of a copolymer which forms tubes at a high pH can be manipulated to give the appropriate degree of pH response in order to ultimately develop a suitable delivery system.

Identifier
DOI https://doi.org/10.5286/ISIS.E.84801788
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/84801788
Provenance
Creator Mr Alexander Chen; Professor Nigel Slater; Dr Ian Tucker; Dr Rongjun Chen; Dr Radka Petkova; Dr Robert Dalgliesh
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences
Temporal Coverage Begin 2017-03-07T00:00:00Z
Temporal Coverage End 2017-03-10T00:00:00Z