A novel role for the cholinergic basal forebrain nucleus of Meynert in chronic pain via modulation of the prelimbic cortex

DOI

This dataset contains all raw electrophysiology data and associated analysis procedures reported in Oswald et al. Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behaviour via modulation of the prelimbic cortex. Nat Comm (2022). Abstract: The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’s and Parkinson’s dementias. Despite the crucial role of neocortical domains in pain perception, however, the NBM has not been studied in models of chronic pain. Here, using in vivo tetrode recordings in behaving mice, we report that beta and gamma oscillatory activity is evoked in the NBM by noxious stimuli and is facilitated at peak inflammatory pain-like behaviour. Optogenetic and chemogenetic cell-specific, reversible manipulations of NBM cholinergic-GABAergic neurons reveal their role in endogenous control of nociceptive hypersensitivity, which are manifest via projections to the prelimbic cortex, resulting in layer 5-mediated antinociception. Our data unravel the importance of the NBM in top-down control of neocortical processing of pain-like behaviour.

Cheetah, 5.6.3

Matlab, R2018a

Phy, 2.0

Excel, 2016

Two ReadMe files are included in the MATLAB scripts directory

Identifier
DOI https://doi.org/10.11588/data/ET9G9X
Related Identifier https://doi.org/10.21203/rs.3.rs-1309454/v1
Metadata Access https://heidata.uni-heidelberg.de/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.11588/data/ET9G9X
Provenance
Creator Oswald, Manfred Josef (ORCID: 0000-0003-1547-747X); Han, Yechao; Kuner, Rohini ORCID logo
Publisher heiDATA
Contributor Kuner, Rohini
Publication Year 2022
Funding Reference Deutsche Forschungsgemeinschaft SFB 1158
Rights CC BY 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact Kuner, Rohini (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany)
Representation
Resource Type Experimental data; Dataset
Format application/zip
Size 26183997090; 33664570791; 25430653354; 26491772835; 28756153606; 26702547; 52428989968; 50925201831; 47254323926; 47451368914; 51410464209; 46081; 71639
Version 1.0
Discipline Life Sciences; Medicine; Neurosciences
Spatial Coverage Heidelberg University