This dataset includes downcore radiogenic isotope records of Sr and Nd of the siliciclastic detrital sediment fraction of samples from gravity cores MSM44_353-3 (GeoB19927-3) and MSM44_372-4 (GeoB19946-4), collected during cruise MSM44 in the eastern Baffin Bay in summer 2015. The Sr and Nd isotope ratios were measured with the purpose of reconstructing past provenances of the sedimentary material delivered onto the West Greenland shelf. Sample preparation and measurements of radiogenic isotope ratios were performed in the Isotope Geochemistry Laboratory at MARUM—Centre for Marine Environmental Sciences, University of Bremen, Germany. All samples were washed, decarbonised and separated from possible iron-manganese coatings following a procedure by Gutjahr et al. (2007). Sr and Nd were extracted through column separation using TrisKem Sr.specTM resin (method modified after Deniel & Pin, 2001), and TRU.specTM resin and LN.specTM (method by Pin et al., 1994), respectively. Isotopic ratios were analysed with a Thermo Fisher Scientific TritonTM Plus multicollector thermal ionization mass spectrometer (TIMS). The 143Nd/144Nd ratio is reported in the εNd notation relative to the Chondritic Uniform Reservoir (CHUR) value (143Nd/144Nd = 0.512638; Jacobsen and Wasserburg, 1980).