Vibrio vulnificus strain CMCP6 methylome was sequenced in bacteria grown in sterile natural seawater and human serum amended with iron to mimic hemochromatosis. This was done to 1) establish the methylome of V. vulnificus, 2) determine if the methylome changes in response to the environment, and 3) identify changes in methylation that may contribute to a virulent phenotype during the transition from free living to an infectious state.