The Poggio le Guaine (PLG) core was designed to provide a high-resolution age model and a high-resolution relative magnetic paleointensity reference curve for the Aptian-Albian interval of the long normal Cretaceous superchron. The PLG drill hole cored the uppermost Barremian-lowermost Cenomanian succession of the Umbria-Marche Basin deposited in the southern margin of the central-western Tethys Ocean. These pelagic sediments formed following the lithification of the nannofossil-planktonic foraminiferal ooze deposited well above the calcite compensation depth at middle to lower bathyal depths (1000-1500 m) and at ~20°N paleolatitude. This succession extends from the uppermost part of the Maiolica Formation (Tithonian to lower Aptian) through the entire Marne a Fucoidi Formation (lower Aptian to uppermost Albian) to the lower part of the Scaglia Bianca Formation (uppermost Albian to lowermost Cenomanian). Discrete ~8 cm3 cubic samples were cut from the center of the split working halve for paleomagnetic analyses (MS and ARM). A total amount of 1227 cubic samples were collected along the studied portion of the PLG core (from 96.02 to 60.00 m; average sampling resolution of ~3 cm). A total of 355 paleomagnetic cubic samples were also used to measure the stable isotopes (δ18O and δ13C) with a ~10 cm resolution.