The IBS BAG includes teams from IBS (Grenoble) and external groups from CEA-Cadarache (St Paul lez Durance), CEA-Grenoble, CERMAV (Grenoble) et IRBA (Brétigny-sur-Orge). We study the structure-function relationships of proteins and biological macromolecular complexes with a focus on human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2686 proposal and can be grouped under the following themes: host-pathogen interaction, new therapeutic targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR) together with other biophysical and biochemical studies and, more recently, the use of AI (e.g. AlphaFold, Chai-1) to fully understand the complexity of the biological systems under study.