Time-series data of physical oceanography, ocean current velocities, and hydroacoustics were obtained from mooring F4-21 in the Fram Strait from July 2022 to July 2024 as part of the Helmholtz infrastructure program Frontiers in Arctic Marine Monitoring (FRAM) legacy and the West Spitsbergen Current array long-term monitoring. The mooring was deployed during RV Polarstern expedition PS131 (ATWAICE) and recovered during PS143/2 (FRAM/Hausgarten). The attached archive contains raw data files of seven Seabird SBE37 MicroCATs (nominal depths: 51m, 75m, 149m, 251m, 400m, 751m, 1202m; sampling interval 10min/1h), five Seabird SBE56 temperature loggers (nominal depths: 104m, 200m, 299m, 350m, 500m; sampling interval 30s), one upward-looking RDI 150kHz Quartermaster ADCP (nominal depth: 250m; sampling interval 1h), one upward-looking RDI 300kHz Sentinel ADCP (nominal depth: 51m; sampling interval 40 min), two Nortek Aquadopp single-point current meters (nominal depths: 750m, 1203m; sampling interval 20 min). The mooring also included an ASL Acoustic Zooplankton Fish Profiler (nominal depth: 147m) and a Develogic SonoVault hydroacoustic recorder (nominal depth: 300m). Auxiliary information, such as sensor calibration sheets, mooring diagrams, and schedule files, is also provided, if applicable. Additional notes: the SBE56 at 287m was lost; the SBE56 at 339m and 489m stopped recording after 10 months.

The file F4-21.zip contains all available sensor raw data from the mooring F4-21. The structure of the unzipped folders is mooring->sensor/sampler type->serial number->instrument files. All instruments were synchronized to UTC before deployment, and the offset after the recovery is supplied in the respective instrument folder, if available. The archive also contains the sensor calibration sheets/files and relevant sampler schedule files, if available. Finally, mooring schematics are also attached as PDFs in the root folder.The authors are grateful to the captains, crews, and technical/scientific staff of the expeditions PS131 and PS143/2 onboard RV Polarstern. Many individuals have contributed to the conception of the research, the preparation of the instruments, the deployments and recoveries, and the retrieval of the data, which we greatly appreciate. We acknowledge support from the Helmholtz infrastructure program "Frontiers in Arctic Marine Monitoring", and the Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung.