Genome-Wide CRISPR Screens for Toxoplasma Gondii Genes Related to Artemisinin Susceptibility

We used CRISPR to generate pools of T. gondii mutants in the presence of dihydroartemisinin to identify genes that confer increased or decreased sensitivity to this drug. Overall design: We performed three screens in which we looked for mutations that decrease susceptibility to DHA and one screen in which we looked for mutations that increase susceptibility.

Identifier
Source https://data.blue-cloud.org/search-details?step=~01223D1A65939FFCAD5730FDED33E0E5FDB6086F5D6
Metadata Access https://data.blue-cloud.org/api/collections/23D1A65939FFCAD5730FDED33E0E5FDB6086F5D6
Provenance
Instrument Illumina HiSeq 2000; ILLUMINA
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Point 2020-07-07T00:00:00Z