Stretching elastic

DOI

In all mammals, tissue elasticity is conveyed by elastin. Elastin is an essential extracellular matrix protein found within arteries, skin, lungs and elastic cartilage. Elastin's responses to systole and diastole are needed to maintain and regulate blood pressure during and between heartbeats. Tropoelastin is the soluble precursor of elastin and is the most elastic biomaterial known. In solution Tropoelastin is an asymmetric molecule about 20nnm in length with a foot protubance which contains the cell interaction motif. However, little is known about how this protein may deform under shear or extension stresses. By combining SANS with in-situ flow fields, we will determine this response through the visualization of changes in the orientation, shape and size of the protein induced by these flow fields.

Identifier
DOI https://doi.org/10.5286/ISIS.E.63525776
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/63525776
Provenance
Creator Dr Ann Terry; Professor Clair Baldock; Dr Ian Tucker; Professor Tony Weiss; Dr Sarah Rogers; Mr Michael Lockhart
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2015-09-08T08:00:00Z
Temporal Coverage End 2015-09-10T08:00:00Z