Adoption of new medicines in primary care: a comparison between the uptake of new oral anticoagulants and diabetes medicines

DOI

Direct-acting oral anticoagulants (DOACs) were introduced in 2008 for the treatment of thrombo-embolic diseases. Dipeptidyl peptidase-4 inhibitors (DPP4-inhibitors) and glucagon-like peptide-1 receptor agonists (GLP1-agonists), both incretin-based therapies, were introduced in 2007 and (late) 2006 respectively, for the treatment of type 2 diabetes mellitus (T2DM). This study aimed to gain insight in the uptake, practice variation and correlation in the adoption of DOACs and incretin-based therapiesPrescription data from general practices in the Dutch Nivel Primary Care Database from 2007-2019 were used. Per year 46 to 424 general practices and 179,933 to 1,654,376 patients were included. In 2019, the mean percentage of patients per practice using DOACs or incretin-based therapies was 54.9% and 9.7%, respectively. The intraclass correlation coefficient (ICC) decreased from 0.75 to 0.024 for DOACs and from 0.33 to 0.074 for incretin-based medicines during the study period. No clear correlation was found between the prescription of DOACs and incretin-based therapies.

Date: 2023-11-06

Date Submitted: 2023-11-17

Identifier
DOI https://doi.org/10.17026/dans-zkm-vmn4
Metadata Access https://lifesciences.datastations.nl/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.17026/dans-zkm-vmn4
Provenance
Creator K Hek ORCID logo
Publisher DANS Data Station Life Sciences
Contributor L Holst
Publication Year 2023
Rights DANS Licence; info:eu-repo/semantics/closedAccess; https://doi.org/10.17026/fp39-0x58
OpenAccess false
Contact L Holst (Nivel)
Representation
Resource Type Dataset
Format application/x-stata-syntax; application/pdf; application/zip; text/x-fixed-field
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Version 2.0
Discipline Life Sciences; Medicine