Membrane Interaction of Alzheimer's Beta Peptides

DOI

We are currently investigating the membrane effects of monomeric and oligomeric forms of Amyloid β (25-35) peptide. In order to regulate the growth of the oligomeric intermediates that have been implicated as the toxic form of the peptide, we have prepared the peptide using both D- and L- isomers of the amino acids. We wish to establish that both D and L forms interact with phospholipid membranes in exactly the same way and, therefore, wish to collect lamellar neutron diffraction data using well-established protocols, to supplement data from other biophysical techniques including circular dichroism, Langmiur balance and electrical conductance measurements.

Identifier
DOI https://doi.org/10.5291/ILL-DATA.8-02-664
Metadata Access https://data.ill.fr/openaire/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=10.5291/ILL-DATA.8-02-664
Provenance
Creator Deme, Bruno; Bradshaw, Jeremy; Cristiglio, Viviana; Chen, Xiaochao; , Xin
Publisher Institut Laue-Langevin
Publication Year 2014
Rights OpenAccess; info:eu-repo/semantics/openAccess
OpenAccess true
Representation
Resource Type Dataset
Size 2 GB
Version 1
Discipline Particles, Nuclei and Fields