IINS of small proteins - extending the limits.

DOI

We have previously studied proteins with IINS, as well as their building blocks (20 different amino acids). The latter studies of amino acids yielded sharp vibrational peaks which could be interpreted with ab-initio calculations (aClimax) to generate simulated spectra that almost exactly reproduced the experimental ones. However IINS of proteins yielded broad peaks that could not be reproduced by a simple summation of the amino acid spectra. Hence broadening in proteins is due to the varying environments experienced by the amino acids within the 3D structure of the protein. The structural information contained within the IINS spectra for proteins could be exploited. In this proposal we aim to approach this goal by extending the earlier work on amino acids to a peptide of limited length (~15 amino acids).

Identifier
DOI https://doi.org/10.5286/ISIS.E.24081699
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24081699
Provenance
Creator Miss Kay Chan; Professor Bob Ford; Mr Shun Chen
Publisher ISIS Neutron and Muon Source
Publication Year 2014
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2011-03-20T09:20:09Z
Temporal Coverage End 2011-03-22T09:04:18Z