Structure of bacterial outer membranes after attack by primary immunity proteins

DOI

We have now succeeded in getting consistently high-quality data from our unique model of the bacterial outer membrane. This involves achieving a highly asymmetric bilayer with phospholipids on the inside and lipopolysaccharide on the outside. To prove the application of this new model we need to show that it behaves like the natural membrane. We know that host primary immune proteins such as lactoferrin and lysozyme bind and disrupt this membrane. We have already demonstrated this for lysozyme. We wish for extra rapid access time to carry out a limited experimental series to show the effect of lactoferrin which has complex and interesting interactions with outer membranes. This will increase the quality of paper and the opportunity to publish in a high impact journal

Identifier
DOI https://doi.org/10.5286/ISIS.E.59898166
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/59898166
Provenance
Creator Mr Tim Robson; Dr Luke Clifton; Dr Arwel Hughes; Dr Stephen Holt; Professor Jeremy Lakey
Publisher ISIS Neutron and Muon Source
Publication Year 2017
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2014-08-17T23:00:00Z
Temporal Coverage End 2014-08-21T23:00:00Z