Alpha-synuclein is tan intrinsically disordered protein whose aggregates are an hallmark of Parkinson's Disease (PD). Alpha-syn is known to associate with lipid membranes and their interaction and aggregation is believed to be important for the PD pathology. Indeed, the process of amyloid formation has been associated with cell injury through mechanisms that are not understood.The overall goal of this project is a detailed understanding of the amyloid aggregation in the presence of lipid membranes, and molecular level characterization of amyloid-lipid co-aggregates. The use of isotope labels will enable us to detect structural information of the protein-lipids interactions. Focus will be on the amyloid protein alpha-syn together with model lipid membranes with different compositions in order to understand the role of the lipid composition and underlying the driving forces.