<b>Coincidence detection in aspiny interneuron dendrites</b>: ex vivo data, NEURON files, and python code used for computational modelling

DOI

Coincidence detection in aspiny interneuron dendritesSimonas Griesius1, Amy Richardson1, Marion Mercier1, Dimitri M Kullmann11 Department of Epilepsy, UCL Queen Square Institute of Neurology,University College London, London, WC1N 3BG, United KingdomCorresponding authorCorrespondance: s.griesius@ucl.ac.uk or d.kullmann@ucl.ac.uk********************Repository contains ex vivo data (LTP induction, backpropagating action potentials and dendritic calcium fluorescence)Repository also contains files necessary to recreate the simulations used in the paper.*********************Install the NEURON simulation environment.Compile the .mod and .hoc filesRun the Jupyter notebooks.Notes books may have key lines of code at the top that can be comment and uncommentto specify important simulations settings - such as presence or absence of induced somaticaction potential spikes or synaptic input.Notebooks:asynch_and_nearsynch_uncaging_simulation.ipynb - fig 1, 2, 7tbs_ltp.ipynb - fig 4somatic_action_potential_spikes_and_synaptic_input_dendrite_26.ipynb - fig 5stdp_calcium.ipynb - fig 7, 8ngf_iclamp_step - fig 1heatmap_plot.ipynb - reads a .csv to make heatmaps used in the paper.

Identifier
DOI https://doi.org/10.5522/04/30104491.v2
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Metadata Access https://api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:figshare.com:article/30104491
Provenance
Creator Griesius, Simon; Richardson, Amy; Mercier, Marion; Kullmann, Dimitri Michael
Publisher University College London UCL
Contributor Figshare
Publication Year 2025
Rights https://creativecommons.org/licenses/by-nc-nd/4.0/; http://purl.org/coar/access_right/c_abf2
OpenAccess true
Contact researchdatarepository(at)ucl.ac.uk
Representation
Language English
Resource Type Software
Discipline Life Sciences; Medicine; Neurosciences