Dataset from the manuscript:
"Novel approaches to model effects of subconjunctival blebs on flow
pressure to improve clinical grading systems after glaucoma drainage
surgery" published with the journal PLOS One. The total size of the data is less than 100
kB.
Each set of data is named with
the figure number of the article.
They are matrices obtained and
formatted with Matlab (R2017b, The MathWorks, Inc., Natick, MA, USA).
The variables within each matrix
correspond to the axis of each figure from the article.
The experimental method for
collection is described extensively in the PLOS One article (DOI soon
available) and summarised below.
The ex vivo experiments
were conducted at the UCL Institute of Ophthalmology. Blebs were prepared using
an ex vivo approach as performed in conventional GFS/GDD surgery. The PEEK tube
connecting the anterior chamber to the bleb was hooked up to a reservoir
of a dilute aqueous solution of Coomassie Brilliant Blue G250. The tube and
reservoir are connected to a microfluidic pressure pump and flow sensor setup
(Fluigent, Villejuif, France). The eye experiments ran for up to 4 hours, and
the pressure was recorded at a low frequency of 1 Hz. The bleb dimensions increase with time and
the measurements of the bleb height, H,
and radius, R, is estimated by
photographic assessment through image processing algorithms written in Matlab.
The in vitro
model experiments were conducted in the environmental fluid mechanics
laboratory located in the UCL Department of Mechanical Engineering. The bleb
height was estimated using calibrated bespoke image processing algorithms
written in Matlab similarly to the ex
vivo approach. A 3-way luer lock connector was used to connect a calibrated
pressure transducer to the inlet tube. The pressure signal was converted to
volts (P8055-1 Velleman 2003) and recorded at a frequency of 1.875 Hz.
