Primary data associated with reassessing the factor structure of the WHOQOL-BREF. The file includes two data sets: Study 1 (exploratory factor analysis), with a sample of 968 users recruited from three medical centers (395 men and 573 women, aged 18 to 91 years old - M = 45.96 and SD = 16.32); and from Study 2 (confirmatory factor analyses), with 1,900 participants (953 men and 947 women, aged 18 to 28 years - M = 25.03 and SD = 2.5). study 2 also includes the data from the Satisfaction with Life Scale (SWLS) in order to establish the concurrent validity of the WHOQOL-BREF.