We explore recently developed temperature proxies based on hydroxylated isoprenoid Glycerol Dialkyl Glycerol Tetraethers (OH-isoGDGTs), such as %OH, RI-OH, RI-OH' and TEX86OH for their potential for reconstructing temperature changes in the Mediterranean Sea and the Red Sea. These OH-isoGDGT-based proxies have not been adequately explored in these semi-enclosed basins. Here we explore the proxies derived from the OH-GDGTs from surface sediments from the Red Sea and Balearic Sea, and compile it with previously published data from the Gulf of Lions (Varma et al., 2023, doi:10.1016/j.gca.2023.12.019 (GCA)). The excel sheet contains information regarding the surface sediments, their location, enivironmental parameters from each location extracted from WOA and NISPP AVHRR database, peak area of iso-GDGTs and OH-isoGDGTs, proxy indices discussed in the study and references for previously published data. These surface sediments were previously explored for GDGT-based proxy, TEX86 and published along with the papers Trommer et al. (2009, doi:10.1016/j.orggeochem.2009.03.001), OG; and Kim et al. (2015, doi:10.1016/j.gca.2014.11.017), GCA.