This research is aimed at analyzing the structure of hollow and solid Prussian Blue (PB) nanoparticles and of bulk PB, by means of total scattering. Our main objective is to study the local structure of these three different forms of PB, particularly the behavior of the material at the surface. PB and its analogues have a wide range of potential applications, such as gas storage, drug delivery, energy storage and catalysis. It is fundamental to achieve a deeper understanding of the structure of these materials in order to address questions related to their applications. This research is part of a project, partly funded by ISIS, whose scope is to understand how to resolve the local structure of nanomaterials, combing the technique of total scattering with the reverse Monte Carlo refinement (using RMCprofile code) and comparing the data with the result of molecular dynamics simulation.