3D resorbable scaffolds are promising materials suitable to restore tendon injuries since it is possible to recreate the spatial organization of the original tissue to allow easier homing of cells, overcoming the problems arising from permanent implants, while supporting the mechanical load until the complete regeneration of the new tissue. The aim of the proposal is the structural characterization by USAXS/SAXS of biomechano-responsive 3D polymeric scaffolds, both porous and fibrous. The evolution of the scaffolds under mechanical stress and their resilience will be observed to assess the nanoscale response to a mechanical solicitation. Results will help in the multiple-length-scale mechanic analysis of thermoplastic-based scaffolds, able to improve surgical repair or reconstruction of tendons/ligaments.