Understanding and controlling the interaction of nanoparticles with biomaterials is key to alleviation of concerns about nanotoxicity. This knowledge can also be used to design ways to retain defined structures as required for nanofabrication using self-assembled particles. Studies of the simplest model systems are an initial key step. The present proposal is to use neutron reflection and off-specular scattering to observe the organisation of polystyrene latex particles on a protein layer. Moringa oleifera seed protein binds strongly and irreversibly to silica and at macroscopic interfaces such as those on large silicon crystals. The protein also binds to latex particles and these processes are important in understanding water purification using the protein as flocculent. The attractive interaction and binding can also provide a means to lock particles in particular structures.