Digital Appendix: Glyco-STORM: lectins as a new labeling tool to decipher the nanoarchitecture of cells

DOI

This is the digital appendix to the dissertation with the title "Glyco-STORM: lectins as a new labeling tool to decipher the nanoarchitecture of cells" by Helene Schröter. In this study, previous obstacles in studying the glycome were overcome by combining fluorophore-conjugated lectins – carbohydrate-binding proteins – with super-resolution microscopy. This approach was termed Glyco-STORM and led to the establishment of new anatomical markers to analyse the architecture of cell organelles and synaptic specializations on the nanoscale. Since lectins reflect the carbohydrate-specific morphology of the underlying structures, the results enable a new – ‘glyco-centric’ – picture of cell machineries, achieving a new level in understanding the function of biological systems. Cracking the ‘sugar code’ by using lectins as labels in a biological context could bring a breakthrough in understanding health and disease of organisms.

Identifier
DOI https://doi.org/10.11588/DATA/Q6YWJ2
Metadata Access https://heidata.uni-heidelberg.de/oai?verb=GetRecord&metadataPrefix=oai_datacite&identifier=doi:10.11588/DATA/Q6YWJ2
Provenance
Creator Schröter, Helene ORCID logo
Publisher heiDATA
Contributor Schröter, Helene; Dr. rer. nat. Maja Klevanski; Prof. Dr. med. Thomas Kuner
Publication Year 2025
Funding Reference Heidelberg University Medical Faculty
Rights CC BY 4.0; info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0
OpenAccess true
Contact Schröter, Helene (Heidelberg University, Functional Neuroanatomy)
Representation
Resource Type Dataset
Format text/tab-separated-values; text/x-objcsrc
Size 4797; 28376; 20157; 19524; 96856; 45603
Version 1.0
Discipline Anatomy; Basic Biological and Medical Research; Biology; Life Sciences; Medicine; Medicine and Health; Physiology