This dataset presents concentration of cytokines and antibodies in broncho-alveolar lavages (BAL) collected from children presenting severe asthma (n=20) and age-matched disease control children (n=10). Using commercial kits, we determined the concentrations of the following immune soluble components in BAL fluids, for each individual: APRIL/TNFSF13, BAFF/TNFSF13B, sCD30/TNFRSF8, sCD163, Chitinase 3-like 1, CCL21 (6Ckine), CXCL13 (BCA-1), CCL27 (CTACK), CXCL25 (ENA-78), CCL11 (Eotaxin), CCL24 (Eotaxin-2), CCL26 (Eotaxin-3), CX3CL1 (Fractalkine), CXCL6 (GCP-2), GM-CSF, CXCL1 (Gro-α), CXCL2 (Gro-β), CCL1 (I-309), gp130/sIL-6Rβ, sIL-6Rα, IFNα2, IFNβ, IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8 (CXCL8), IL-10, IL-11, IL-12p40, IL-12p70, IL-16, IL-19, IL-20, IL-22, IL-26, IL-27 (p28), IL-28A (IFN-2λ), IL-29 (IFN-λ1), IL-32, IL-34, IL-35, CXCL10 (IP-10), CXCL11 (I-TAC), CCL2 (MCP-1), CCL8 (MCP-2), CCL7 (MCP-3), CCL13 (MCP4), CCL22 (MDC), MIF, CXCL9 (MIG), CCL3 (MIP-1α), CCL15 (MIP-1δ), CCL20 (MIP-3α), CCL19 (MIP-3β), CCL23 (MPIF-1), CXCL16 (SCYB16), CXCL12 (SDF-1α+β), CCL17 (TARC), CCL25 (TECK), LIGHT/TNFSF14, MMP-1, MMP-2, MMP-3, Osteocalcin, Osteopontin (OPN), Pentraxin-3, sTNF-R1, sTNF-R2, TLSP, TNFα, and TWEAK/TNFSF12, total IgG, total IgA. Total IgE were also assessed using in-lab immunoassay (DOI: 10.1016/0091-6749(86)90378-7). Concentrations are expressed as pg/ml for cytokines, ng/ml for antibodies. A first oneblock analysis of corresponding dataset is described in doi: 10.3389/fimmu.2021.700521. Our aim is to identify a local signature of severe asthma by conducting comprehensive multi-omics analysis of BALs from children with severe asthmatic versus non-asthmatic controls. Corresponding multi-omics data will be described in a data paper under submission, also describing all corresponding metadata.