Our BAG was created in 2006 to federate well-established structural biology laboratories from south Paris. So far, several projects were investigated by different teams from 5 Institutes: (1) I2BC (Institut de Biologie Integrative de la Cellule), (2) IBPC (Institut de Biologie Physico-Chimique), (3) INSERM (InstitutNational de la Sante et de la Recherche Medicale), (4) LBPA (Laboratoire de Biologie et Pharmacologie Applique#e) and (5) CiTCoM (CiblesTherapeutiques et Conception de Medicaments, ex-name LCRB). Starting from 2025, Pasteur institute will join our BAG to reinforce the interaction between structural biology teams in Paris and Ile de France. Our research area focuses on many important biological systems involved in human pathology or infectious diseases, including molecular chaperones, DNA recombination, RNA maturation, ribosome biogenesis, telomerase assembly, bacterial toxins, malaria disease, neurodegenerative disease, drugs resistance and cell-signalling.